Friday, October 13, 2023 was the school day in the Village des Sciences, at the Palais Universitaire. The MITO team was there to familiarise the "youngest generation of scientists"…
Targeting of CRISPR-Cas12a crRNAs into human mitochondria
A new genome-wide method that marries classical enzymatic kinetics, deep sequencing, and mathematical modelling - CoLoC-seq - has been created in the MITO team and successfully…
Editorial for a special issue of Frontiers Physiology
Theoretical and mathematical biology paper about hub-centred RNA-protein networks
Friday, October 13, 2023 was the school day in the Village des Sciences, at the Palais Universitaire. The MITO team was…
Our comprehensive review on the fascinating ribosome assembly GTPase Era/ERAL1 is out!
Anyone who wants to have a clear & reliable idea about RNA localisation inside/outside membrane-bounded organelles,…
Targeting of CRISPR-Cas12a crRNAs into human mitochondria
Théo Markezic, funded by IMCBio, starts his PhD studies in the "RNA-binding hubs" group.
Our review paper on the evolutionary significance of RNA-binding proteins of the FinO/ProQ family has been published in…
Dr Sissler works on diverse aspects of mitochondrial RNA biology. She is particularly interested in mitochondrial…
We are proud to present a great collection of papers published in the Special issue "Research progress in RNA-binding…
A new genome-wide method that marries classical enzymatic kinetics, deep sequencing, and mathematical modelling -…
Editorial for a special issue of Frontiers Physiology
Our comprehensive review on the fascinating ribosome assembly GTPase Era/ERAL1 is out!
Anyone who wants to have a clear & reliable idea about RNA localisation inside/outside membrane-bounded organelles, extracellular vesicles, or viral particles can now use this detailed protocol. It includes all reagents & equipment necessary to perform CoLoC-seq experiments, a step-by-step protocol,…
Our review paper on the evolutionary significance of RNA-binding proteins of the FinO/ProQ family has been published in Bioscience Reports.
We are proud to present a great collection of papers published in the Special issue "Research progress in RNA-binding proteins" of International Journal of Molecular Sciences - editorial by Alexandre Smirnov.
A new genome-wide method that marries classical enzymatic kinetics, deep sequencing, and mathematical modelling - CoLoC-seq - has been created in the MITO team and successfully applied to human mitochondria to tell resident RNAs from contaminants.
Editorial for a special issue of Frontiers Physiology
Theoretical and mathematical biology paper about hub-centred RNA-protein networks
Efficient target cleavage by Type V Cas12a effectors programmed with split CRISPR RNA Nucleic Acids Res. 2021 Dec 24. pii: gkab1227. doi: 10.1093/nar/gkab1227. Online ahead of print. Regina Shebanova 1, Natalia Nikitchina 1 2, Nikita Shebanov 1, Vladimir Mekler 3, Konstantin Kuznedelov 3, Egor…
Meschaninova MI, Entelis NS, Chernolovskaya EL, Venyaminova AG (2021) A versatile solid-phase approach to the synthesis of oligonucleotide conjugates with biodegradable hydrazone linker. Molecules 26:2119 One of the ways to efficiently deliver various drugs, including therapeutic nucleic acids,…
Our big review on stable RNPs and the complexomic approaches to profile them , including Grad-seq, co-authored with the Jörg Vogel's lab, is availbale in Frontiers in Molecular Biosciences: Gerovac M, Vogel J, Smirnov A (2021) The world of stable ribonucleoproteins and its mapping with Grad-seq…
The FASEB Journal Early View RESEARCH ARTICLE Open Access Staphylococcus aureus Panton-Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria Viola Mazzoleni Gaëlle Zimmermann-Meisse Anna Smirnova Ivan Tarassov Gilles Prévost First…
Karine Auré, Guillemette Fayet, Ivan Chicherin, Benoit Rucheton, Sandrine Filaut, Anne-Marie Heckel, Julie Eichler, Florence Caillon, Yann Péréon, Nina Entelis, Ivan Tarassov, Anne Lombès (2020) A homoplasmic mitochondrial tRNAPro mutation causing exercise-induced muscle swelling and fatigue.…
YBEY is an essential biogenesis factor for mitochondrial ribosomes Nucleic Acids Res. 2020 Mar 17. pii: gkaa148. doi: 10.1093/nar/gkaa148. [Epub ahead of print] Summer S1, Smirnova A2, Gabriele A2, Toth U1, Fasemore AM3, Förstner KU3,4,5, Kuhn L6, Chicher J6, Hammann P6, Mitulovi? G7, Entelis N2, …
IUBMB Life. 2018 Sep 5. doi: 10.1002/iub.1919. [Epub ahead of print] Can Mitochondrial DNA be CRISPRized: Pro and Contra. Loutre R1, Heckel AM1, Smirnova A1, Entelis N1, Tarassov I1. Author information Abstract Mitochondria represent a chimera of macromolecules encoded either in the…
R. Loutre, AM Heckel, D Jeandard, I Tarassov, N Entelis (2018) "Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner" PLOS ONE https://doi.org/10.1371/journal.pone.0199258 Abstract Mutations in mitochondrial DNA are an important source of…
I. Dovydenko, I. Tarassov, A. Venyaminova, N. Entelis (2015) Method of carrier-free delivery of therapeutic RNA importable into human mitochondria: lipophilic conjugates with cleavable bonds. Biomaterials (in press) BIOMATERIALS is one of the leading journals in the field of molecular therapy and…
