The MITO team created an innovative subcellular transcriptomics approach, CoLoC-seq - Nucleic Acids Research A new genome-wide method that marries classical enzymatic kinetics, deep sequencing, and mathematical modelling - CoLoC-seq - has been created in the MITO team and successfully…
New publication of the MITO team in Computational and Structural Biotechnology Journal Theoretical and mathematical biology paper about hub-centred RNA-protein networks
Junior chairs in the field of research on mitochondria The Laboratory of Excellence (LabEx) MitoCross announces the call for applications for two junior chairs in the field of research on mitochondria.
Our detailed CoLoC-seq protocol is published in Bio-protocol Anyone who wants to have a clear & reliable idea about RNA localisation inside/outside membrane-bounded organelles,…
The MITO team welcomes a new PhD student, Théo Markezic Théo Markezic, funded by IMCBio, starts his PhD studies in the "RNA-binding hubs" group.
Review on the evolutionary aspects of the FinO/ProQ family proteins Our review paper on the evolutionary significance of RNA-binding proteins of the FinO/ProQ family has been published in…
The MITO team welcomes a new member, Dr Marie SISSLER (CNRS) Dr Sissler works on diverse aspects of mitochondrial RNA biology. She is particularly interested in mitochondrial…
Editorial for the Special issue "Research progress in RNA-binding proteins" - International Journal of Molecular Sciences We are proud to present a great collection of papers published in the Special issue "Research progress in RNA-binding…
The MITO team created an innovative subcellular transcriptomics approach, CoLoC-seq - Nucleic Acids Research A new genome-wide method that marries classical enzymatic kinetics, deep sequencing, and mathematical modelling -…
New publication of the MITO team in Computational and Structural Biotechnology Journal Theoretical and mathematical biology paper about hub-centred RNA-protein networks
Junior chairs in the field of research on mitochondria The Laboratory of Excellence (LabEx) MitoCross announces the call for applications for two junior chairs in the field of…
Our detailed CoLoC-seq protocol is published in Bio-protocol Anyone who wants to have a clear & reliable idea about RNA localisation inside/outside membrane-bounded organelles, extracellular vesicles, or viral particles can now use this detailed protocol. It includes all reagents & equipment necessary to perform CoLoC-seq experiments, a step-by-step protocol,…
Review on the evolutionary aspects of the FinO/ProQ family proteins Our review paper on the evolutionary significance of RNA-binding proteins of the FinO/ProQ family has been published in Bioscience Reports.
Editorial for the Special issue "Research progress in RNA-binding proteins" - International Journal of Molecular Sciences We are proud to present a great collection of papers published in the Special issue "Research progress in RNA-binding proteins" of International Journal of Molecular Sciences - editorial by Alexandre Smirnov.
The MITO team created an innovative subcellular transcriptomics approach, CoLoC-seq - Nucleic Acids Research A new genome-wide method that marries classical enzymatic kinetics, deep sequencing, and mathematical modelling - CoLoC-seq - has been created in the MITO team and successfully applied to human mitochondria to tell resident RNAs from contaminants.
New publication of the MITO team in Computational and Structural Biotechnology Journal Theoretical and mathematical biology paper about hub-centred RNA-protein networks
New publication of the MITO team in Nucleic Acids Research Efficient target cleavage by Type V Cas12a effectors programmed with split CRISPR RNA Nucleic Acids Res. 2021 Dec 24. pii: gkab1227. doi: 10.1093/nar/gkab1227. Online ahead of print. Regina Shebanova 1, Natalia Nikitchina 1 2, Nikita Shebanov 1, Vladimir Mekler 3, Konstantin Kuznedelov 3, Egor…
Our paper in collaboration with the Alya Venyaminova's team has been published in Molecules Meschaninova MI, Entelis NS, Chernolovskaya EL, Venyaminova AG (2021) A versatile solid-phase approach to the synthesis of oligonucleotide conjugates with biodegradable hydrazone linker. Molecules 26:2119 One of the ways to efficiently deliver various drugs, including therapeutic nucleic acids,…
Congratulations on a fantastic 2021 series of review & protocol papers from the MITO team! Our big review on stable RNPs and the complexomic approaches to profile them , including Grad-seq, co-authored with the Jörg Vogel's lab, is availbale in Frontiers in Molecular Biosciences: Gerovac M, Vogel J, Smirnov A (2021) The world of stable ribonucleoproteins and its mapping with Grad-seq…
A FASEB J. paper by the MITO team The FASEB Journal Early View RESEARCH ARTICLE Open Access Staphylococcus aureus Panton-Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria Viola Mazzoleni Gaëlle Zimmermann-Meisse Anna Smirnova Ivan Tarassov Gilles Prévost First…
New publication by MITO team in Neurology: Genetics Karine Auré, Guillemette Fayet, Ivan Chicherin, Benoit Rucheton, Sandrine Filaut, Anne-Marie Heckel, Julie Eichler, Florence Caillon, Yann Péréon, Nina Entelis, Ivan Tarassov, Anne Lombès (2020) A homoplasmic mitochondrial tRNAPro mutation causing exercise-induced muscle swelling and fatigue.…
New publication of the MITO team in Nucleic Acids Research YBEY is an essential biogenesis factor for mitochondrial ribosomes Nucleic Acids Res. 2020 Mar 17. pii: gkaa148. doi: 10.1093/nar/gkaa148. [Epub ahead of print] Summer S1, Smirnova A2, Gabriele A2, Toth U1, Fasemore AM3, Förstner KU3,4,5, Kuhn L6, Chicher J6, Hammann P6, Mitulovi? G7, Entelis N2, …
New paper in IUBMB life by MITO-team. IUBMB Life. 2018 Sep 5. doi: 10.1002/iub.1919. [Epub ahead of print] Can Mitochondrial DNA be CRISPRized: Pro and Contra. Loutre R1, Heckel AM1, Smirnova A1, Entelis N1, Tarassov I1. Author information Abstract Mitochondria represent a chimera of macromolecules encoded either in the…
New paper in PLoS ONE for the MITO-team R. Loutre, AM Heckel, D Jeandard, I Tarassov, N Entelis (2018) "Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner" PLOS ONE https://doi.org/10.1371/journal.pone.0199258 Abstract Mutations in mitochondrial DNA are an important source of…
MITO-Team : paper accepted in BIOMATERIALS I. Dovydenko, I. Tarassov, A. Venyaminova, N. Entelis (2015) Method of carrier-free delivery of therapeutic RNA importable into human mitochondria: lipophilic conjugates with cleavable bonds. Biomaterials (in press) BIOMATERIALS is one of the leading journals in the field of molecular therapy and…