AARS Online is an interactive Wikipedia-like tool curated by an international consortium of aminoacyl-tRNA synthetase (aaRS) experts. Accessible at www.aars.online, it is a free resource to delve into the world of aaRSs, key players of the mRNA translation process. AARS Online systematizes existing…
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma. doi.org/10.1038/s41556-024-01439-2 Transfer RNA dynamics contribute to cancer development through regulation of codon-specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either promote or suppress…
Our comprehensive review on the fascinating ribosome assembly GTPase Era/ERAL1 is out!
Anyone who wants to have a clear & reliable idea about RNA localisation inside/outside membrane-bounded organelles, extracellular vesicles, or viral particles can now use this detailed protocol. It includes all reagents & equipment necessary to perform CoLoC-seq experiments, a step-by-step protocol,…
Our review paper on the evolutionary significance of RNA-binding proteins of the FinO/ProQ family has been published in Bioscience Reports.
We are proud to present a great collection of papers published in the Special issue "Research progress in RNA-binding proteins" of International Journal of Molecular Sciences - editorial by Alexandre Smirnov.
A new genome-wide method that marries classical enzymatic kinetics, deep sequencing, and mathematical modelling - CoLoC-seq - has been created in the MITO team and successfully applied to human mitochondria to tell resident RNAs from contaminants.
Theoretical and mathematical biology paper about hub-centred RNA-protein networks
Efficient target cleavage by Type V Cas12a effectors programmed with split CRISPR RNA Nucleic Acids Res. 2021 Dec 24. pii: gkab1227. doi: 10.1093/nar/gkab1227. Online ahead of print. Regina Shebanova 1, Natalia Nikitchina 1 2, Nikita Shebanov 1, Vladimir Mekler 3, Konstantin Kuznedelov 3, Egor…
Meschaninova MI, Entelis NS, Chernolovskaya EL, Venyaminova AG (2021) A versatile solid-phase approach to the synthesis of oligonucleotide conjugates with biodegradable hydrazone linker. Molecules 26:2119 One of the ways to efficiently deliver various drugs, including therapeutic nucleic acids,…
Our big review on stable RNPs and the complexomic approaches to profile them , including Grad-seq, co-authored with the Jörg Vogel's lab, is availbale in Frontiers in Molecular Biosciences: Gerovac M, Vogel J, Smirnov A (2021) The world of stable ribonucleoproteins and its mapping with Grad-seq…
The FASEB Journal Early View RESEARCH ARTICLE Open Access Staphylococcus aureus Panton-Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria Viola Mazzoleni Gaëlle Zimmermann-Meisse Anna Smirnova Ivan Tarassov Gilles Prévost First…
Karine Auré, Guillemette Fayet, Ivan Chicherin, Benoit Rucheton, Sandrine Filaut, Anne-Marie Heckel, Julie Eichler, Florence Caillon, Yann Péréon, Nina Entelis, Ivan Tarassov, Anne Lombès (2020) A homoplasmic mitochondrial tRNAPro mutation causing exercise-induced muscle swelling and fatigue.…
YBEY is an essential biogenesis factor for mitochondrial ribosomes Nucleic Acids Res. 2020 Mar 17. pii: gkaa148. doi: 10.1093/nar/gkaa148. [Epub ahead of print] Summer S1, Smirnova A2, Gabriele A2, Toth U1, Fasemore AM3, Förstner KU3,4,5, Kuhn L6, Chicher J6, Hammann P6, Mitulovi? G7, Entelis N2, …
IUBMB Life. 2018 Sep 5. doi: 10.1002/iub.1919. [Epub ahead of print] Can Mitochondrial DNA be CRISPRized: Pro and Contra. Loutre R1, Heckel AM1, Smirnova A1, Entelis N1, Tarassov I1. Author information Abstract Mitochondria represent a chimera of macromolecules encoded either in the…
R. Loutre, AM Heckel, D Jeandard, I Tarassov, N Entelis (2018) "Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner" PLOS ONE https://doi.org/10.1371/journal.pone.0199258 Abstract Mutations in mitochondrial DNA are an important source of…
I. Dovydenko, I. Tarassov, A. Venyaminova, N. Entelis (2015) Method of carrier-free delivery of therapeutic RNA importable into human mitochondria: lipophilic conjugates with cleavable bonds. Biomaterials (in press) BIOMATERIALS is one of the leading journals in the field of molecular therapy and…
