Équipe Tarassov-Smirnov - MITO - GMGM - Génétique moléculaire, génomique, microbiologie - Université de Strasbourg https://gmgm.unistra.fr fr Équipe Tarassov-Smirnov - MITO - GMGM - Génétique moléculaire, génomique, microbiologie - Université de Strasbourg Wed, 17 Apr 2024 05:48:59 +0200 Wed, 17 Apr 2024 05:48:59 +0200 TYPO3 EXT:news news-14807 Mon, 16 Oct 2023 15:09:10 +0200 Bacteria, mitochondria, ribosomes & evolution at the Fête de la Science 2023 /en/news/piece-of-news/bacteria-mitochondria-ribosomes-evolution-at-the-fete-de-la-science-2023 Friday, October 13, 2023 was the school day in the Village des Sciences, at the Palais Universitaire. The MITO team was there to familiarise the "youngest generation of scientists" with bases of cellular and molecular biology. Kids and adults from over 20 Alsatian schools discovered the amazing world of bacteria, mitochondria and ribosomes & their evolutionary journey. They could see (and smell!) real bacteria grown in the lab, play with structures of ribosomes to see how they changed over a billion years of evolution, and study electron microscopy photos to learn to recognise healthy and dysfunctional mitochondria.

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Actualités du GMGM Actualités de l'Équipe Tarassov-Smirnov Focus de l'équipe Tarassov-Smirnov
news-14766 Wed, 04 Oct 2023 14:00:17 +0200 GTPase Era at the heart of ribosome assembly /en/news/piece-of-news/gtpase-era-at-the-heart-of-ribosome-assembly Our comprehensive review on the fascinating ribosome assembly GTPase Era/ERAL1 is out! Gruffaz C & Smirnov A (2023) GTPase Era at the heart of ribosome assembly. Front Mol Biosci 10:1263433

Ribosome biogenesis is a key process in all organisms. It relies on coordinated work of multiple proteins and RNAs, including an array of assembly factors. Among them, the GTPase Era stands out as an especially deeply conserved protein, critically required for the assembly of bacterial-type ribosomes from Escherichia coli to humans. In this review, we bring together and critically analyze a wealth of phylogenetic, biochemical, structural, genetic and physiological data about this extensively studied but still insufficiently understood factor. We do so using a comparative and, wherever possible, synthetic approach, by confronting observations from diverse groups of bacteria and eukaryotic organelles (mitochondria and chloroplasts). The emerging consensus posits that Era intervenes relatively early in the small subunit biogenesis and is essential for the proper shaping of the platform which, in its turn, is a prerequisite for efficient translation. The timing of Era action on the ribosome is defined by its interactions with guanosine nucleotides [GTP, GDP, (p)ppGpp], ribosomal RNA, and likely other factors that trigger or delay its GTPase activity. As a critical nexus of the small subunit biogenesis, Era is subject to sophisticated regulatory mechanisms at the transcriptional, post-transcriptional, and post-translational levels. Failure of these mechanisms or a deficiency in Era function entail dramatic generalized consequences for the protein synthesis and far-reaching, pleiotropic effects on the organism physiology, such as the Perrault syndrome in humans.

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Actualités de l'Équipe Tarassov-Smirnov Publications de l'Équipe Tarassov-Smirnov
news-14728 Thu, 21 Sep 2023 17:04:54 +0200 Our detailed CoLoC-seq protocol is published in Bio-protocol /en/news/piece-of-news/our-detailed-coloc-seq-protocol-is-published-in-bio-protocol Anyone who wants to have a clear & reliable idea about RNA localisation inside/outside membrane-bounded organelles, extracellular vesicles, or viral particles can now use this detailed protocol. It includes all reagents & equipment necessary to perform CoLoC-seq experiments, a step-by-step protocol, and useful tips for data analysis & interpretation! Smirnova AJeandard DSmirnov A (2023) Controlled Level of Contamination Coupled to Deep Sequencing (CoLoC-seq) probes the global localisation topology of organelle transcriptomesBio-protocol 13: e4820

Information on RNA localisation is essential for understanding physiological and pathological processes, such as gene expression, cell reprogramming, host–pathogen interactions, and signalling pathways involving RNA transactions at the level of membrane-less or membrane-bounded organelles and extracellular vesicles. In many cases, it is important to assess the topology of RNA localisation, i.e., to distinguish the transcripts encapsulated within an organelle of interest from those merely attached to its surface. This allows establishing which RNAs can, in principle, engage in local molecular interactions and which are prevented from interacting by membranes or other physical barriers. The most widely used techniques interrogating RNA localisation topology are based on the treatment of isolated organelles with RNases with subsequent identification of the surviving transcripts by northern blotting, qRT-PCR, or RNA-seq. However, this approach produces incoherent results and many false positives. Here, we describe Controlled Level of Contamination coupled to deep sequencing (CoLoC-seq), a more refined subcellular transcriptomics approach that overcomes these pitfalls. CoLoC-seq starts by the purification of organelles of interest. They are then either left intact or lysed and subjected to a gradient of RNase concentrations to produce unique RNA degradation dynamics profiles, which can be monitored by northern blotting or RNA-seq. Through straightforward mathematical modelling, CoLoC-seq distinguishes true membrane-enveloped transcripts from degradable and non-degradable contaminants of any abundance. The method has been implemented in the mitochondria of HEK293 cells, where it outperformed alternative subcellular transcriptomics approaches. It is applicable to other membrane-bounded organelles, e.g., plastids, single-membrane organelles of the vesicular system, extracellular vesicles, or viral particles.

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Actualités de l'Équipe Tarassov-Smirnov Publications de l'Équipe Tarassov-Smirnov
news-14686 Fri, 15 Sep 2023 09:31:51 +0200 New publication by MITO-team /en/news/piece-of-news/new-publication-by-mito-team Targeting of CRISPR-Cas12a crRNAs into human mitochondria BIOCHIMIE

Mitochondrial gene editing holds great promise as a therapeutic approach for mitochondrial diseases caused by mutations in the mitochondrial DNA (mtDNA). Current strategies focus on reducing mutant mtDNA heteroplasmy levels through targeted cleavage or base editing. However, the delivery of editing components into mitochondria remains a challenge. Here we investigate the import of CRISPR-Cas12a system guide RNAs (crRNAs) into human mitochondria and study the structural requirements for this process by northern blot analysis of RNA isolated from nucleases-treated mitoplasts. To investigate whether the fusion of crRNA with known RNA import determinants (MLS) improve its mitochondrial targeting, we added MLS hairpin structures at 3’-end of crRNA and demonstrated that this did not impact crRNA ability to program specific cleavage of DNA in lysate of human cells expressing AsCas12a nuclease. Surprisingly, mitochondrial localization of the fused crRNA molecules was not improved compared to non-modified version, indicating that structured scaffold domain of crRNA can probably function as MLS, assuring crRNA mitochondrial import. Then, we designed a series of crRNAs targeting different regions of mtDNA and demonstrated their ability to program specific cleavage of mtDNA fragments in cell lysate and their partial localization in mitochondrial matrix in human cells transfected with these RNA molecules. We hypothesize that mitochondrial import of crRNAs may depend on their secondary structure/sequence. We presume that imported crRNA allow reconstituting the active crRNA/Cas12a system in human mitochondria, which can contribute to the development of effective strategies for mitochondrial gene editing and potential future treatment of mitochondrial diseases.

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Actualités du GMGM Publications du GMGM Actualités de l'Équipe Tarassov-Smirnov
news-14618 Mon, 04 Sep 2023 11:40:13 +0200 The MITO team welcomes a new PhD student, Théo Markezic /en/news/piece-of-news/the-mito-team-welcomes-a-new-phd-student-theo-markezic Théo Markezic, funded by IMCBio, starts his PhD studies in the "RNA-binding hubs" group. Théo will work on pervasive and antisense transcription in phylogenetically distant bacteria, E. coli and S. aureus, using experimental evolution approaches. His work will take place in GMGM and IBMC under the supervision of Alexandre Smirnov and Isabelle Caldelari. Théo is funded by IMCBio, via the Inter-Labex PhD programme (MitoCross - NetRNA).

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Actualités de l'Équipe Tarassov-Smirnov
news-13132 Thu, 02 Mar 2023 10:34:51 +0100 Review on the evolutionary aspects of the FinO/ProQ family proteins /en/news/piece-of-news/review-on-the-evolutionary-aspects-of-the-fino-proq-family-proteins Our review paper on the evolutionary significance of RNA-binding proteins of the FinO/ProQ family has been published in Bioscience Reports. FinO/ProQ-family proteins: an evolutionary perspective

Zhen Liao & Alexandre Smirnov

Biosci Rep (2023) 43 (3): BSR20220313

RNA-binding proteins are key actors of post-transcriptional networks. Almost exclusively studied in the light of their interactions with RNA ligands and the associated functional events, they are still poorly understood as evolutionary units. In this review, we discuss the FinO/ProQ family of bacterial RNA chaperones, how they evolve and spread across bacterial populations and what properties and opportunities they provide to their host cells. We reflect on major conserved and divergent themes within the family, trying to understand how the same ancestral RNA-binding fold, augmented with additional structural elements, could yield either highly specialised proteins or, on the contrary, globally acting regulatory hubs with a pervasive impact on gene expression. We also consider dominant convergent evolutionary trends that shaped their RNA chaperone activity and recurrently implicated the FinO/ProQ-like proteins in bacterial DNA metabolism, translation and virulence. Finally, we offer a new perspective in which FinO/ProQ-family regulators emerge as active evolutionary players with both negative and positive roles, significantly impacting the evolutionary modes and trajectories of their bacterial hosts.

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Actualités de l'Équipe Tarassov-Smirnov Publications de l'Équipe Tarassov-Smirnov
news-12988 Wed, 25 Jan 2023 13:58:42 +0100 The MITO team welcomes a new member, Dr Marie SISSLER (CNRS) /en/news/piece-of-news/the-mito-team-welcomes-a-new-member-dr-marie-sissler-cnrs Dr Sissler works on diverse aspects of mitochondrial RNA biology. She is particularly interested in mitochondrial aminoacyl-tRNA synthetases in as diverses biological models as humans and trypanosomatids. Dr Sissler studies the basic principles of their orhanisation and molecular functions as well as their involvement in human pathologies. 

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Actualités de l'Équipe Tarassov-Smirnov
news-12872 Wed, 21 Dec 2022 13:43:45 +0100 Editorial for the Special issue "Research progress in RNA-binding proteins" - International Journal of Molecular Sciences /en/news/piece-of-news/editorial-for-the-special-issue-research-progress-in-rna-binding-proteins-international-journal-of-molecular-sciences We are proud to present a great collection of papers published in the Special issue "Research progress in RNA-binding proteins" of International Journal of Molecular Sciences - editorial by Alexandre Smirnov. An editorial by Alexandre Smirnov introduces a great collection of 9 papers dedicated to various aspects of the biology of RNA-binding proteins - now published in International Journal of Molecular Sciences.

Smirnov A (2023) Research progress in RNA-binding proteins. Int J Mol Sci 24:58.

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Actualités de l'Équipe Tarassov-Smirnov Publications de l'Équipe Tarassov-Smirnov
news-12871 Tue, 20 Dec 2022 15:56:02 +0100 The MITO team created an innovative subcellular transcriptomics approach, CoLoC-seq - Nucleic Acids Research /en/news/piece-of-news/the-mito-team-created-an-innovative-subcellular-transcriptomics-approach-coloc-seq-nucleic-acids-research A new genome-wide method that marries classical enzymatic kinetics, deep sequencing, and mathematical modelling - CoLoC-seq - has been created in the MITO team and successfully applied to human mitochondria to tell resident RNAs from contaminants. Damien Jeandard, Anna Smirnova, Akinyemi Mandela Fasemore, Léna Coudray, Nina Entelis, Konrad U Förstner, Ivan Tarassov, Alexandre Smirnov (2023) CoLoC-seq probes the global topology of organelle transcriptomesNucleic Acids Research 51:e16.

Proper RNA localisation is essential for physiological gene expression. Various kinds of genome-wide approaches permit to comprehensively profile subcellular transcriptomes. Among them, cell fractionation methods, that couple RNase treatment of isolated organelles to the sequencing of protected transcripts, remain most widely used, mainly because they do not require genetic modification of the studied system and can be easily implemented in any cells or tissues, including in non-model species. However, they suffer from numerous false-positives since incompletely digested contaminant RNAs can still be captured and erroneously identified as resident transcripts. Here we introduce Controlled Level of Contamination coupled to deep sequencing (CoLoC-seq) as a new subcellular transcriptomics approach that efficiently bypasses this caveat. CoLoC-seq leverages classical enzymatic kinetics and tracks the depletion dynamics of transcripts in a gradient of an exogenously added RNase, with or without organellar membranes. By means of straightforward mathematical modelling, CoLoC-seq infers the localisation topology of RNAs and robustly distinguishes between genuinely resident, luminal transcripts and merely abundant surface-attached contaminants. Our generic approach performed well on human mitochondria and is in principle applicable to other membrane-bounded organelles, including plastids, compartments of the vacuolar system, extracellular vesicles, and viral particles.

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Actualités du GMGM Publications du GMGM Actualités de l'Équipe Tarassov-Smirnov Publications de l'Équipe Tarassov-Smirnov
news-12765 Mon, 21 Nov 2022 15:40:05 +0100 MITO team : editorial in Frontiers Physiology /en/news/piece-of-news/mito-team-editorial-in-frontiers-physiology Editorial for a special issue of Frontiers Physiology Burzio VA, Barrey E, Leucci E, Entelis N,
Hollander JM and Das S (2022)
Editorial:
Role of mitochondria-associated noncoding
RNAs inintracellular communication.
Front. Physiol. 13:980674.
doi: 10.3389/fphys.2022.980674
 

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Actualités du GMGM Publications du GMGM Actualités de l'Équipe Tarassov-Smirnov Publications de l'Équipe Tarassov-Smirnov
news-12713 Mon, 14 Nov 2022 11:05:46 +0100 New publication of the MITO team in Computational and Structural Biotechnology Journal /en/news/piece-of-news/new-publication-of-the-mito-team-in-computational-and-structural-biotechnology-journal Theoretical and mathematical biology paper about hub-centred RNA-protein networks Smirnov A (2022) How global RNA-binding proteins coordinate the behaviour of RNA regulons: an information approach. Comput Struct Biotechnol J doi:10.1016/j.csbj.2022.11.019

RNA-binding proteins are central players in post-transcriptional regulation. Some of them, such as the well-studied bacterial RNA chaperones Hfq and ProQ or the eukaryotic RNAi factor Argonaute, interact with hundreds-to-thousands of different RNAs and thereby globally affect gene expression. As a shared yet limited resource, these and other RNA-binding hubs drive strong competition between their multiple ligands. This creates a ground for significant cross-communication between RNA targets, which enables them to share information, “synchronise” their behaviour, and produce interesting biochemical effects, sometimes propagating across the highly connected RNA-protein network. This property is likely universally present in hub-centred networks and plays a key role in global gene expression programmes. It is also an important factor in biotechnology and synthetic biology applications of RNA/protein-based circuits. However, few studies so-far focused on describing and explaining this phenomenon from first principles. Here we introduce an information theory-based framework to comprehensively and exactly describe information flow in hub-centred networks. We show that information sharing can achieve significant levels in relatively small networks, provided the hub is present in limiting concentrations. The transmitted information is sufficient to noticeably affect the binding probabilities of competing targets but drops exponentially along the network. Target overexpression can disrupt communication between other targets, while hub sequestration boosts the crosstalk. We also find that overlaps between the interactomes of two different hubs create both entropic challenges and new forms of long-range communication between RNAs and proteins.

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Actualités du GMGM Publications du GMGM Actualités de l'Équipe Tarassov-Smirnov Publications de l'Équipe Tarassov-Smirnov
news-12102 Tue, 07 Jun 2022 15:28:00 +0200 Junior chairs in the field of research on mitochondria /en/news/piece-of-news/chaires-juniors-dans-le-domaine-de-recherches-sur-les-mitochondries The Laboratory of Excellence (LabEx) MitoCross announces the call for applications for two junior chairs in the field of research on mitochondria. See details HERE.

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Actualités du GMGM Actualités de l'Équipe Becker Actualités de l'Équipe Tarassov-Smirnov Actualités de l'Équipe Schacherer
news-10578 Fri, 14 Jan 2022 16:48:16 +0100 We welcome XuChu Duan, a visiting researcher from the Nantong University! /en/news/piece-of-news/we-welcome-xuchu-duan-a-visiting-researcher-from-the-nantong-university XuChu, who is a specialist in zebrafish and developmental biology, is doing his sabbatical in our team. He will work on the mechanistic roles of YBEY in coordination of the human mitoribosome assembly.

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Actualités de l'Équipe Tarassov-Smirnov
news-10570 Wed, 12 Jan 2022 11:27:09 +0100 New publication of the MITO team in Nucleic Acids Research /en/news/piece-of-news/new-publication-of-the-mito-team-in-nucleic-acids-research-1 Efficient target cleavage by Type V Cas12a effectors programmed with split CRISPR RNA

 

Nucleic Acids Res. 2021 Dec 24. pii: gkab1227. doi: 10.1093/nar/gkab1227. Online ahead of print.

Regina Shebanova 1Natalia Nikitchina 1 2Nikita Shebanov 1Vladimir Mekler 3Konstantin Kuznedelov 3Egor Ulashchik 4Ruslan Vasilev 5 6Olga Sharko 4Vadim Shmanai 4Ivan Tarassov 2Konstantin Severinov 1 3 7Nina Entelis 2Ilya Mazunin 1

 

Abstract

CRISPR RNAs (crRNAs) that direct target DNA cleavage by Type V Cas12a nucleases consist of constant repeat-derived 5'-scaffold moiety and variable 3'-spacer moieties. Here, we demonstrate that removal of most of the 20-nucleotide scaffold has only a slight effect on in vitro target DNA cleavage by a Cas12a ortholog from Acidaminococcus sp. (AsCas12a). In fact, residual cleavage was observed even in the presence of a 20-nucleotide crRNA spacer moiety only. crRNAs split into separate scaffold and spacer RNAs catalyzed highly specific and efficient cleavage of target DNA by AsCas12a in vitro and in lysates of human cells. In addition to dsDNA target cleavage, AsCas12a programmed with split crRNAs also catalyzed specific ssDNA target cleavage and non-specific ssDNA degradation (collateral activity). V-A effector nucleases from Francisella novicida (FnCas12a) and Lachnospiraceae bacterium (LbCas12a) were also functional with split crRNAs. Thus, the ability of V-A effectors to use split crRNAs appears to be a general property. Though higher concentrations of split crRNA components are needed to achieve efficient target cleavage, split crRNAs open new lines of inquiry into the mechanisms of target recognition and cleavage and may stimulate further development of single-tube multiplex and/or parallel diagnostic tests based on Cas12a nucleases.

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Actualités du GMGM Actualités de l'Équipe Tarassov-Smirnov Publications de l'Équipe Tarassov-Smirnov
news-9580 Wed, 22 Apr 2020 16:46:00 +0200 New publication of the MITO team in Nucleic Acids Research /en/news/piece-of-news/new-publication-of-the-mito-team-in-nucleic-acids-research

YBEY is an essential biogenesis factor for mitochondrial ribosomes

Nucleic Acids Res. 2020 Mar 17. pii: gkaa148. doi: 10.1093/nar/gkaa148. [Epub ahead of print]

Abstract

Ribosome biogenesis requires numerous trans-acting factors, some of which are deeply conserved. In Bacteria, the endoribonuclease YbeY is believed to be involved in 16S rRNA 3'-end processing and its loss was associated with ribosomal abnormalities. In Eukarya, YBEY appears to generally localize to mitochondria (or chloroplasts). Here we show that the deletion of human YBEY results in a severe respiratory deficiency and morphologically abnormal mitochondria as an apparent consequence of impaired mitochondrial translation. Reduced stability of 12S rRNA and the deficiency of several proteins of the small ribosomal subunit in YBEY knockout cells pointed towards a defect in mitochondrial ribosome biogenesis. The specific interaction of mitoribosomal protein uS11m with YBEY suggests that the latter helps to properly incorporate uS11m into the nascent small subunit in its late assembly stage. This scenario shows similarities with final stages of cytosolic ribosome biogenesis, and may represent a late checkpoint before the mitoribosome engages in translation.

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Actualités du GMGM Actualités de l'Équipe Tarassov-Smirnov Publications de l'Équipe Tarassov-Smirnov
news-9578 Thu, 12 Mar 2020 14:59:00 +0100 USIAS 2020 award for Alexandre Smirnov /en/news/piece-of-news/usias-2020-award-for-alexandre-smirnov The Institute for Advanced Studies at the University of Strasbourg (USIAS) is committed to supporting an original type of research and potentially pioneering research, so as to promote a high level of reflection and synthesis.

Among 2020 USIAS supported projects is that of Alexandre Smirnov: "Experimental evolution of an organism with devastating impairment of regulatory networks".

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Actualités du GMGM Actualités de l'Équipe Tarassov-Smirnov
news-9557 Mon, 03 Dec 2018 09:37:00 +0100 Anne-Marie Heckel à la rencontre des Lycéens /en/news/piece-of-news/anne-marie-heckel-a-la-rencontre-des-lyceens Anne-Marie Heckel, ingénieure de l'équipe MITO, avait présenté nos thématiques de recherche aux lycéens. La rencontre a été mise en lumière par deux publications locales (DNA).

Voir l'article 1

Voir l'article 2

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Actualités du GMGM Actualités de l'Équipe Tarassov-Smirnov
news-9545 Thu, 26 Oct 2017 16:45:00 +0200 Le projet d’École Universitaire de recherche en biologie moléculaire et cellulaire intégrative incluant le LabEx MitoCross - lauréat du Programme d’investissements d’avenir. /en/news/piece-of-news/le-projet-decole-universitaire-de-recherche-en-biologie-moleculaire-et-cellulaire-integrative-incluant-le-labex-mitocross-laureat-du-programme-dinvestissements-davenir Basé sur un regroupement stratégique des forces strasbourgeoises en biologie moléculaire et cellulaire des trois Laboratoire d'excellence (LabEx) INRT (IGBMC), MitoCross (GMGM, IBMP et IBMC(ARN)) et NetRNA (IBMC (ARN, RIDI), IBMP), avec le concours d’outils technologiques de pointe tels que les quatre Infrastructures nationales en biologie santé (INBS) CELPHEDIA/PHENOMIN, FRISBI, France Génomique et Ingestem ainsi que l’Équipement d'excellence (EquipEx) I2MC, le projet d’Ecole universitaire de recherche (EUR) Integrative Molecular and Cellular Biology (IMCBio) a été retenu, mardi 24 octobre, dans le cadre du Programme d’investissements d’avenir (PIA3). Ce projet de formation inédit est l’une des quatre EUR lauréates portées par l’Université de Strasbourg qui se voit dotée d’un montant de 25 717 000 € pour l’ensemble de ces projets. À travers des stages en laboratoires additionnels, des modules de formations complémentaires au niveau Master, des écoles d’étés, ou encore un programme de formation de haut niveau pour le doctorat, l’EUR IMCBio souhaite attirer des étudiants ayant une forte motivation pour la recherche pour former les futurs chercheurs capables de travailler aux interfaces de la Biologie. Avec le soutien conjoint de l’Université de Strasbourg (Faculté des sciences de la Vie et Ecole doctorale Vie et Santé), du CNRS et de l’Inserm, ce projet, qui s’appuie sur le modèle de « graduate school », a pour triple ambition de lier fortement la formation à la recherche, de valoriser les points forts thématiques du site de Strasbourg mais aussi de concourir à son rayonnement international.

Le troisième PIA qui finance ce projet se veut en effet structurant pour le paysage de l’enseignement supérieur et de la recherche française et vise à offrir aux sites universitaires la possibilité de renforcer l’impact et l’attractivité internationale de leur recherche et de leur formation dans un ou plusieurs domaine(s) scientifique(s). Dans le cadre des EUR, cette structuration passe par le rassemblement des formations de master et de doctorat adossées à un ou plusieurs laboratoires de recherche de haut niveau. Sur 195 projets déposés, 29 lauréats de cette première vague du PIA3, pour un montant de 216 M€ financés sur dix ans, ont été conjointement annoncés par le ministère de l’Enseignement supérieur, de la Recherche et de l’Innovation et le Commissaire général à l’investissement, précisant avoir suivi l’avis d’un jury international.

 

Contacts :

Directeur du projet : Bertrand Séraphin, directeur de recherche, CNRS

Codirecteur du projet : Nicolas Matt, Maître de conférences, Université de Strasbourg

Représentants des LabEx: INRT (Bertrand Séraphin), MitoCross (Ivan Tarassov), NetRNA (Pascale Romby)

 

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Actualités du GMGM Actualités de l'Équipe Tarassov-Smirnov
news-9443 Fri, 02 Nov 2012 16:21:00 +0100 Le consortium MitoCross se dote d'un site web ! /en/news/piece-of-news/le-consortium-mitocross-se-dote-dun-site-web L'objectif global du consortium MitoCross est d'approfondir les connaissances et mécanismes moléculaires fins gouvernant la biogenèse des mitochondries, leur fonctionnement et leur communication avec les autres compartiments cellulaires. En exploitant des modèles d'étude différents que sont la levure, les plantes et l'homme, les nouvelles connaissances acquises permettront de développer des outils innovants en termes biotechnologique et biomédical.

Le consortium MitoCross se dote d'un site web dédié. Sa conception a été assurée conjointement par les personnels du consortium et le département Web et diffusion scientifique de la DUN. Ce site est en outre hébergé sur les serveurs de la Direction Informatique (DI) de l'université.

Nous espérons qu'il répondra à vos attentes et vous souhaitons une excellente navigation : mitocross.unistra.fr

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Actualités du GMGM Actualités de l'Équipe Tarassov-Smirnov
news-9441 Thu, 16 Feb 2012 16:47:00 +0100 LabEx : La Mitochondrie Strasbourgeoise à l'Honneur /en/news/piece-of-news/labex-la-mitochondrie-strasbourgeoise-a-lhonneur  2 équipes de l'unité ont été labélisées

MitoCross

Le projet Laboratoires d’Excellence (LabEx) Investissement d’Avenir vise à soutenir des projets scientifiques phare portés par des équipes de recherche et des laboratoires au meilleur niveau international. Les résultats de l’appel à projet de la 2ème vague ont été annoncés le 14 Février et mettent à l’honneur un consortium de 6 équipes Strasbourgeoises (UMR 7167 GMGM, UPR 2357 IBMP et UPR 9002 ARN), avec pour élément féderateur la mitochondrie. L'objectif global du consortium MitoCross est d'approfondir les connaissances et mécanismes moléculaires fins gouvernant la biogenèse des mitochondries, leur fonctionnement et leur communication avec les autres compartiments cellulaires. En exploitant des modèles d'étude différents que sont la levure, les plantes et l'homme, les nouvelles connaissances acquises permettront de développer des outils innovants en termes biotechnologique et biomédical.

Pour en savoir plus : consultez le site du projet

Genomes expression and cross-talk in mitochondrial function and dysfunction

Project manager: I. Tarassov (I.Tarassov[at]unistra.fr)

  • UMR 7156 (GMGM): teams N. Entelis & I. Tarassov; H. Becker
  • UPR 2357 (IBMP): teams L. Drouard; A. Dietrich; P. Giegé
  • UPR 9002 (ARN): team C. Florentz  & M. Sissler
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Actualités du GMGM Actualités de l'Équipe Tarassov-Smirnov